Monday, January 10, 2022

Pakistani-American Surgeon Transplants Pig Heart into A Human Patient

Pakistani-American heart surgeon Dr. Mohammad Mansoor Mohiuddin and Dr. Bartley Griffith performed the first successful genetically-modified pig heart transplant into a human patient today at University of Maryland School of Medicine (UMSOM) hospital in Baltimore, according to the University's press release. Considered one of the world’s foremost experts on transplanting animal organs, known as xenotransplantation, Muhammad M. Mohiuddin, MD, Professor of Surgery at UMSOM, joined the UMSOM faculty five years ago and established the Cardiac Xenotransplantation Program with Dr. Griffith. Dr. Mohiuddin serves as the program’s Scientific/Program Director and Dr. Griffith as its Clinical Director.    

Dr. Mohammad Mansoor Mohiuddin



Dr. Mohiuddin is a 1989 graduate of the Dow University of Health Sciences, Karachi, Pakistan. He came to the United States in the early 1990s and did a fellowship in Transplantation Biology and Immunology, Department of Cardiothoracic Surgery Harrison Department of Surgical Research, University of Pennsylvania Medical Center, Philadelphia, PA . 

A practicing Muslim, he believes it is acceptable to use pig organs if it helps save human life.  Some Islamic scholars have ruled that it is prohibited to use pig for organ transplants. However, almost all research in the field of xenotransplantation is now carried out using pigs. Researchers say pigs are a preferred choice because they grow fast and the size of their organs is similar to that of humans. There is a worldwide shortage of organ donors. Successful use of genetically modified pig hearts and other organs will help save lives in the absence of human donors. 

The U.S. Food and Drug Administration granted emergency authorization for the surgery on New Year’s Eve through its expanded access (compassionate use) provision. It is used when an experimental medical product, in this case the genetically-modified pig’s heart, is the only option available for a patient faced with a serious or life-threatening medical condition. The authorization to proceed was granted in the hope of saving the patient’s life, according to a UMSOM press release. 

 “This is the culmination of years of highly complicated research to hone this technique in animals with survival times that have reached beyond nine months. The FDA used our data and data on the experimental pig to authorize the transplant in an end-stage heart disease patient who had no other treatment options,” said Dr. Mohiuddin. “The successful procedure provided valuable information to help the medical community improve this potentially life-saving method in future patients.”  

About 30% of the 800,000 doctors, or about 240,000 doctors, practicing in America are of foreign origin, according to Catholic Health Association of the United States. Predictions vary, but according to the American Association of Medical Colleges, by 2025 the U.S. will be short about 160,000 physicians. This gap will most likely be filled by more foreign doctors.

Foreign Doctors in US, UK. Source: OECD



As of 2013, there were over 12,000 Pakistani doctors, or about 5% of all foreign physicians and surgeons, in practice in the United States.  Pakistan is the third largest source of foreign-trained doctors. India tops with 22%, or 52,800 doctors. It is followed by the Philippines with 6%, or 14,400 foreign-trained doctors. India and Pakistan also rank as the top two sources of foreign doctors in the United Kingdom.

Over half a million Pakistani-Americans constitute the 7th largest Asian ethnic group in the United States. Pakistani-Americans are young, well-educated and prosperous. Median age for Pakistani-Americans is 31.7 years. 60% have at least a bachelor's degree. Their median household income is $87,510 a year.  Last year, the remittances from Pakistani-Americans jumped 58% to $2.75 billion.

Here's a video clip of Dr. Mohiuddin describing the procedure and the science behind genetic modification of pig heart for human transplant:

https://youtu.be/D00T14balpI

 


Related Links:

Haq's Musings

South Asia Investor Review

Pakistani-American Health Professional Featured in Netflix Documentary "Pandemic"

Pakistan is the 3rd Largest Source of Foreign Doctors in America

Pakistani-Americans Largest Foreign-Born Muslim Group in Silicon Valley

Racial Slurs Hurled at Pakistani-American Doctor in St. Louis, Missouri

Islamophobia in America

Silicon Valley Pakistani-Americans

Pakistani-American Leads Silicon Valley's Top Incubator

Silicon Valley Pakistanis Enabling 2nd Machine Revolution

Karachi-born Triple Oscar Winning Graphics Artist

Pakistani-American Ashar Aziz's Fire-eye Goes Public

Pakistani-American Doctor Honored By President Obama

Pakistani-American's Game-Changing Vision 

Minorities Are Majority in Silicon Valley 


6 comments:

Riaz Haq said...

Excerpts of "Our Man", biography of late Richard Holbrooke, President Obama's Special Representative for Afghanistan and Pakistan (SRAP), by George Packer

Holbrooke died in December 13,2010 after his aorta ruptured.

His emergency heart surgery was performed by Dr. Farzad Najam, a Pakistani-American heart surgeon at George Washington Hospital in Washington DC.

-------------------


Hillary Clinton’s doctor, Jehan El-Bayoumi, worked at George Washington and heard from a Clinton aide that an important person was coming their way. A young cardiologist named Monica Mukherjee met the ambulance at the doors and led the gurney through the emergency room to radiology.

--------

Mukherjee called the hospital’s chief cardiac surgeon, who was fifteen minutes away. “You need to come right now. It’s a VIP.” “Who is it?” “His name is (Richard) Holbrooke.” He was wheeled into the triage trauma bay and a curtain was drawn around the gurney. Feldman was on his left side, holding his hand, and LaVine was at the foot of the bed. Mukherjee was trying to get a catheter into his right wrist to monitor blood pressure, but he was in such turmoil that she couldn’t do it. His skin was cold and clammy and he looked as if he was about to pass out, but Mukherjee was struck by how he dominated the room—not just his size but his sheer presence, the light in his ice-blue eyes.

--------------------

They wheeled him to the elevator and took him up to the second floor. He kept instructing Feldman. “Tell Mort Janklow. No, wait till the operation is over, and don’t release a press statement till it’s over.” In the intensive care unit the surgeon introduced himself. “Mr. Holbrooke, I am Dr. Farzad Najam, the cardiac surgeon here.” “Any Indian-American doctor is okay with me,” Holbrooke said. Still putting on. Najam and Mukherjee exchanged a look. Najam was a Pakistani American, from Lahore. He knew about Holbrooke’s work. “Just tell me it’s going to be okay.” “Mr. Holbrooke, you have an acute aortic dissection—the aorta has ripped. It’s a surgical emergency and we need to take you to the operating room.” Najam would have to cut through the breastbone, put him on a bypass pump, and replace the aorta and perhaps the valve.


Packer, George. Our Man . Knopf Doubleday Publishing Group. Kindle Edition.

Riaz Haq said...

The following article from the Journal of American Medical Association (JAMA) says there are 14,352 Pakistan-i-American doctors of in America.


https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2767883

Prevalence of International Medical Graduates From Muslim-Majority Nations in the US Physician Workforce From 2009 to 2019

John R. Boulet, PhD; Robbert J. Duvivier, MD, PhD; William W. Pinsky, MD


Of 1 065 606 physicians in the American Medical Association Physician Masterfile, 263 029 (24.7%) were IMGs, of whom 48 354 were citizens of Muslim-majority countries at time of entry to medical school, representing 18.4% of all IMGs. Overall, 1 in 22 physicians in the US was an IMG from a Muslim-majority nation, representing 4.5% of the total US physician workforce. More than half of IMGs from Muslim-majority nations (24 491 [50.6%]) come from 3 countries: Pakistan (14 352 [29.7%]), Iran (5288 [10.9%]), and Egypt (4851 [10.0%]). The most prevalent specialties include internal medicine (10 934 [23.6%]), family medicine (3430 [7.5%]), pediatrics (2767 [5.9%]), and psychiatry (2251 [4.8%]), with 18 229 (38.1%) practicing in primary care specialties. The number of applicants for Educational Commission for Foreign Medical Graduates certification from Muslim-majority countries increased from 2009 (3227 applicants) to 2015 (4244 applicants), then decreased by 2.1% in 2016 to 4254 applicants, 4.3% in 2017 to 4073 applicants, and 11.5% in 2018 to 3604 applicants. Much of this decrease could be attributed to fewer citizens from Pakistan (1042 applicants in 2015 to 919 applicants in 2018), Egypt (493 applicants in 2015 to 309 applicants in 2018), Iran (281 applicants in 2015 to 182 applicants in 2018), and Saudi Arabia (337 applicants in 2015 to 163 applicants in 2018) applying for certification.

Anonymous said...

Highest concentration of monosaturated oils are found in peanut/groundnut oil.

So why is the West obsessed with OLIVE oil?

Here is why..
https://www.indexmundi.com/agriculture/?commodity=olive-oil&graph=production

Europe & Israel are major producers.

Why no study of groundnut/peanut oil?

https://www.indexmundi.com/agriculture/?commodity=peanut-oil&graph=production

This research is actually a marketing scam by the West.

Riaz Haq said...

As of 2016, there were 12,454 Pakistani doctors and 45,830 Indian doctors out of 215,630 total in the United States.


https://stats.oecd.org/Index.aspx?QueryId=68336

India 45,830

Pakistan 12,454

Grenada 10,789

Philipines 10,217

Dominica 9,974

Mexico 9,923

Canada 7,765

Dominican Republic 6,269

China 5,772

UAE 4,635

Egypt 4,379

------------

Total Foreign Doctors in UK 66,211

India 18,953

Pakistan 8,026

Nigeria 4,880

Egypt 4,471

Foreign Doctors in Canada 25,400:

South Africa 2,604

India 2,127

Ireland 1,942

UK 1,923


US 1,263


Pakistan 1,087

Riaz Haq said...

Dr. Monica Mukherjee (Indian) and Dr. Farzad Najam (Pakistani) doctors did emergency surgery on Richard Holbrooke (Obama's Special Rep for Afghanistan and Pakistan) at George Washington University Hospital in Washington DC. Here's an except from George Packer's biography of Holbrooke:

Hillary Clinton’s doctor, Jehan El-Bayoumi, worked at George Washington and heard from a Clinton aide that an important person was coming their way. A young cardiologist named Monica Mukherjee met the ambulance at the doors and led the gurney through the emergency room to radiology. Holbrooke was screaming in pain. Mukherjee tried to settle him down for the CT scan. She could already tell that his aorta had torn. She didn’t know who he was but he seemed gigantic to her, much too long for the gurney. His enormous feet almost fell off the end. No blood was reaching those feet and their distress was now extreme. Feldman stepped away to call the doctors in New York.

“Where’s Dan,” Holbrooke demanded, “where’s Dan?” “You have to calm down,” Mukherjee told him. The scan showed a Type A aortic dissection, meaning straight to surgery. In the secretary of state’s office the force of his heart pounding blood under immense pressure through the stressed and weakened aneurysm had torn a hole in the aorta’s inner layer, and as blood streamed between the layers the torn flaps blocked the flow to the spinal arteries, and his lower half was cut off.

Mukherjee called the hospital’s chief cardiac surgeon (Dr. Farzad Najam), who was fifteen minutes away. “You need to come right now. It’s a VIP.” “Who is it?” “His name is Holbrooke.” He was wheeled into the triage trauma bay and a curtain was drawn around the gurney. Feldman was on his left side, holding his hand, and LaVine was at the foot of the bed. Mukherjee was trying to get a catheter into his right wrist to monitor blood pressure, but he was in such turmoil that she couldn’t do it. His skin was cold and clammy and he looked as if he was about to pass out, but Mukherjee was struck by how he dominated the room—not just his size but his sheer presence, the light in his ice-blue eyes. She was still struggling with the IV. “This may hurt.”

---
He closed his eyes. “I hate the beach.” “Okay, what do you like?” He opened them and looked at Mukherjee. “I like beautiful women.” Mukherjee was getting a little annoyed. El-Bayoumi told him again to relax. “I can’t relax. I’m in charge of Afghanistan and Pakistan.” “And Iraq?” “No, I don’t care about Iraq. I’m trying to bring peace to Afghanistan.” “Just relax,” El-Bayoumi said. “Let me worry about Afghanistan.” “Fine. You end the war.” He was handed consent forms to sign but was in too much pain to read them. “I have a problem with the second clause,” he said, putting on. He signed.

They wheeled him to the elevator and took him up to the second floor. He kept instructing Feldman. “Tell Mort Janklow. No, wait till the operation is over, and don’t release a press statement till it’s over.” In the intensive care unit the surgeon introduced himself. “Mr. Holbrooke, I am Dr. Farzad Najam, the cardiac surgeon here.” “Any Indian-American doctor is okay with me,” Holbrooke said. Still putting on. Najam and Mukherjee exchanged a look. Najam was a Pakistani American, from Lahore. He knew about Holbrooke’s work. “Just tell me it’s going to be okay.” “Mr. Holbrooke, you have an acute aortic dissection—the aorta has ripped. It’s a surgical emergency and we need to take you to the operating room.” Najam would have to cut through the breastbone, put him on a bypass pump, and replace the aorta and perhaps the valve.

Packer, George. Our Man . Knopf Doubleday Publishing Group. Kindle Edition.

Riaz Haq said...

Migration of academics: Economic development does not necessarily lead to brain drain

https://phys.org/news/2023-01-migration-academics-economic-necessarily-brain.html

A team of researchers at the Max Planck Institute for Demographic Research (MPIDR) in Rostock, Germany, developed a database on international migration of academics in order to assess emigration patterns and trends for this key group of innovators. Their paper was published in PNAS on Jan. 18.

As a first step, the team produced a database that contains the number of academics who publish papers regularly, and migration flows and migration rates for all countries that include academics who published papers listed on the bibliographic database Scopus. The migration database was obtained by leveraging metadata of more than 36 million journal articles and reviews published from 1996 to 2021.

"This migration database is a major resource to advance our understanding of the migration of academics," says MPIDR Researcher Ebru Sanliturk. Data Scientist Maciej Danko adds: "While the underlying data are proprietary, our approach generates anonymized aggregate-level datasets that can be shared for noncommercial purposes and that we are making publicly available for scientific research."

MPIDR Researcher Aliakbar Akbaritabar explains how they processed the bibliographic data in order to receive information about the migration patterns of academics: "We used the metadata of the article title, name of the authors and affiliations of almost every article and review published in Scopus since 1996. We followed every single one of the roughly 17 million researchers listed in the bibliographic database through the years and noticed changes in affiliation and, by using that tactic we know how many academics left a given country every year."

The researchers' empirical analysis focused on the relationship between emigration and economic development, indicating that academic setting patterns may differ widely from population-level ones.

Previous literature has shown that, as low-income countries become richer, overall emigration rates initially rise. At a certain point the increase slows down and the trend reverses, with emigration rates declining.

This means that favoring economic development has the counterintuitive effect of initially increasing migration from low- and middle-income countries, rather than decreasing it.

Is this pattern also generally valid for migration of scientists?

Not really.

The researchers found that, when considering academics, the pattern is the opposite: in low- and middle-income countries, emigration rates decrease as the gross domestic product (GDP) per capita increases. Then, starting from around 25,000 US Dollars in GDP, the trend reverses and emigration propensity increases as countries get richer.

MPIDR Director Emilio Zagheni adds, "Academics are a crucial group of innovators whose work has relevant economic effects. We showed that their propensity to emigrate does not immediately increase with economic development—indeed it decreases until a high-income turning point and then increases. This implies that increasing economic development does not necessarily lead to an academic brain drain in low- and middle-income countries."

Unveiling these and related patterns, and addressing big scientific questions with societal implications, was possible only because of painstaking work in preparing this new global database of migration of academics. "We are putting the final touches on an even more comprehensive database, the Scholarly Migration Database, which will be released on its own website soon," says software developer Tom Theile.